Suc-LLVY-amc (20 M) was incubated with 15 nM purified human being 26S proteasome in the absence or presence of SOP6, gliotoxin or BTZ (20 M each). ETPs inhibit Rpn11 and other JAMM proteases Chetomin is an ETP that was initially identified as a toxic secondary metabolite from fungi (Geiger, 1949). Interestingly, chetomin was identified as … Continue reading Suc-LLVY-amc (20 M) was incubated with 15 nM purified human being 26S proteasome in the absence or presence of SOP6, gliotoxin or BTZ (20 M each)